Monoamine ligands

B) polysiloxane-immobilized monoamine ligand, (S)-CH2CH2CH2NH2, of the untreated... 

The NMR spectrum of the untreated polysiloxane-immobilized monoamine ligand (Fig. 25.lA) shows three signals, at 10.7, 27.4 and 44.9 ppm, whereas the spectrum of the corresponding protonated system (washed with... 

The CRAMPS spectrum of the polysiloxane-immobilized thiol-monoamine ligand system (Fig. 25.16B) shows no signal due to NH2 protons. This may be in part because the signal of the NH2 groups is broadened by the " N quadrupole effect on MAS averaging of the H- " N dipolar interaction, and in part because of effects of proton exchange of NH2 protons. Quadrupo-lar line broadening effects of N on attached protons have previously been observed in CRAMPS spectra of amino acids and other systems (72-74). 

Monoamine ligands in ruthenium(II) complexes have been reported to undergo oxidative dehydrogenation to imines benzylamine affords benzaldimine (and benzonitrile) [7] and cyclohexylamine yields cyclohexanone imine [8]. 

Neurotransmitter transport can be electrogenic if it results in the net translocation of electrical charge (e.g. if more cations than anions are transferred into the cell interior). Moreover, some transporters may direction-ally conduct ions in a manner akin to ligand-gated ion channels this ion flux is not coupled to substrate transport and requires a separate permeation pathway associated with the transporter molecule. In the case of the monoamine transporters (DAT, NET, SERT) the sodium current triggered by amphetamine, a monoamine and psychostimulant (see Fig. 4) is considered responsible for a high internal sodium concentration... 

In the monoamine receptors the ligand-binding domain is located within the transmembrane helices. A pocket is formed between TM3, TM5 and TM6 where the agonist binds. A conserved aspartate residue in TM3 (Asp-113 in the /(-adrenoceptor) and a... 

The affinity (Kj values) observed for [ H]MDA and [ HJMDMA binding were similar to the effective doses (i.e., ED50 or K] values) of MDA and MDMA reported for various pre- and postsynaptic monoamine markers, such as serotonin and dopamine release (Johnson et al. 1986), monoamine transport (Steele et al. 1987), and multiple brain, ligand binding sites (Battaglia et al. 1988). 

A versatile synthesis of monoamine platinum(II) complexes of the type ptCl3(amine)], where the nature of the amine ligand can be varied readily, involves treatment of the iodo-bridged dimer [PtI(/r-I)L]2 (L = NH3, methylamine, ethylamine, isopropylamine, cyclobutylamine, and... 

Fig. 24. Monoamine Monoamide Dithiols (MAMA) - a new N2S2 ligand system [170,171]...

Zheng G Dwoskin LP, Deacinc AG Norrhohn SD, Crooks PA. (2005) Defnnctionalized lobeline analognes Strnctnre-affinity of novel ligands for the vesicnlar monoamine transporter. J Med Chem 48 5551-5560. 

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