Acylcarnitine hydrolase

Esterase ESI5 Acylcarnitine hydrolase Carboxylesterase RL2 Esterase pi 5.5 Hydrolase pi 5.6 Acylcarnitine hydrolase Esterase Esterase I Esterase ES10 Carboxylesterase RH1 Octanoylglycerol lipase Esterase pi 6.1 Hydrolase pi 6.2... 

R. Mentlein, H. Rix-Matzen, E. Heymann, Subcellular Localization of Nonspecific Carboxylesterases, Acylcarnitine Hydrolase, Monoacylglycerol Lipase and Palmitoyl-CoA Hydrolase in Rat Liver , Biochim. Biophys. Acta 1988, 964, 319-328. 

Figure 3. Mitochondrial fatty acid oxidation. Long-chain fatty acids are converted to their CoA-esters as described in the text, and their fatty-acyl-groups transferred to CoA in the matrix by the concerted action of CPT 1, the acylcarnitine/carnitine exchange carrier and CPT (A) as described in the text. Medium-chain and short-chain fatty acids (Cg or less) diffuse directly into the matrix where they are converted to their acyl-CoA esters by a acyl-CoA synthase. The mechanism of p-oxidation is shown below (B). Each cycle of P-oxidation removes -CH2-CH2- as an acetyl unit until the fatty acids are completely converted to acetyl-CoA. The enzymes catalyzing each stage of P-oxidation have different but overlapping specificities. In muscle mitochondria, most acetyl-CoA is oxidized to CO2 and H2O by the citrate cycle (Figure 4) some is converted to acylcamitine by carnitine acetyltransferase (associated with the inner face of the inner membrane) and exported from the matrix. Some acetyl-CoA (if in excess) is hydrolyzed to acetate and CoASH by acetyl-CoA hydrolase in the matrix. Enzymes ...

---