Mono-O-methylated flavanols

Steffen Y, Gruber C, Schewe T, Sies H. 2008. Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase. Arch Biochem Biophys 469 209-219. 

Recently, the biological impact of dietary polyphenols has been associated with the endothelial metabolism of NO. In particular, it has been shown that mono-O-methylated flavanols and other flavonoids by inhibition of endothelial NADPH oxidase suppress the formation of superoxide radical, that otherwise eliminates NO via diffusion-controlled formation of peroxynitrite (Steffen et al, 2008). Such a mechanism, preserving or enhancing the bioavailability of NO, may underlie the improvement of vascular endothelial function by certain flavonoid structures and its metabolites via, for instance, dilation of arterial vessels and lowering of blood pressure (Steffen et al, 2008). 

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See also in sourсe #XX -- [ ]

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