Monitoring particle growth during

Application of High-Speed, Integrated, Computerized, Hydrodynamic Chromatography for Monitoring Particle Growth During Latex Polymerization... 

In this publication monitoring of different particle growth patterns during latex polymerizations using the high speed computerized HDC will be described for S/B latexes. Kinetic information will not be dealt with in this paper. 

Consider the results from Zhdanov et al. reproduced in Fig. 2 [27], which were reported previously by Zhdanov and Samulevich [28], based on a technique reported by Zhdanov in 1971 [29]. In that figure, the apparent nucleation history of the synthesis system was determined by monitoring the growth of several of the largest crystals in the system over time, determining the crystal size distribution of the final crystalline zeolite product, and using both sets of data to estimate when each class of particles had been nucleated during the synthesis. The same technique has been used by others [7,30-32] with very similar results. 

There are many different applications of the DLS technique. The DLS method has been used to determine the size of polymer lattices and resins and to monitor the growth of particles during processes such as emulsification and polymerization. Micelles and microemulsions have been studied by DLS methods. DLS is also widely applicable to the investigation of biopolymers and biocolloids. It has been used to study natural and synthetic polypeptides, nucleic acids, ribosomes, vesicles, viruses, and muscle fibers. 

Information on particle size distribution during crystallization can provide valuable insight into the nucleation and crystal growth behaviors of the system. An increase in total particle count and a decrease in particle size could represent nucleation. An increase in particle size with a similar particle count could mean crystal growth. Example 7-2 shows the use of online monitoring PSD for the development of crystallization processes. 

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