Molybdopterin-containing enzymes formate dehydrogenase

The three known crystal structures of molybdopterin-containing enzymes are from members of the first two families the aldehyde oxido-reductase from D. gigas (MOP) belongs to the xanthine oxidase family (199, 200), whereas the DMSO reductases from Rhodobacter (R.) cap-sulatus (201) and from/ , sphaeroides (202) and the formate dehydrogenase from E. coli (203) are all members of the second family of enzymes. There is a preliminary report of the X-ray structure for enzymes of the sulfite oxidase family (204). 

Formate dehydrogenases from many bacteria contain molybdopterin and also often selenium (Table 15-4).664/665 A membrane-bound Mo-containing formate dehydrogenase is produced by E. coli grown anaerobically in the presence of nitrate. Under these circumstances it is coupled to nitrate reductase via an electron-transport chain in the membranes which permits oxidation of formate by nitrate (Eq. 18-26). This enzyme is also a multisubunit protein.665 666 Two other Mo- and Se- containing formate dehydrogenases are produced... 

Khangulov, S. V., Gladyshev, V. N., Dismukes, G. C., and Stadtman, T. C., 1998, Selenium-containing formate dehydrogenase H from Escherichia coli a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer. Biochemistry 37 351893528. 

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