Molybdenum enzymes crystallographic studies

From recent x-ray crystallographic studies of both molybdenum and tungsten enzymes, MPT is now known to be a C(6)-substituted 5,6-dihydropterin that is covalently alkoxylated at the C(7) position by the alcohol of the 1,2-enedithio-late side chain (Eq. 1) [39],... 

Thanks to several protein crystallographic studies and a wealth of spectroscopic information, we now have a good basis for understanding the structure-function relationships of the molybdenum and tungsten enzymes. In each... 

There are several recent reviews of the molybdenum and tungsten enzymes [4-6,23,26-36], In this chapter, we first define the metallocofactors and offer a compilation of the enzymes and their diverse activities. We then focus on the active-site structures, highlighting the confluence of crystallographic and spectroscopic studies. This is followed by a discussion of pertainent spectroscopic, structural, reactivity, and theoretical model studies. We then turn our attention to the mechanisms of catalytic activity of the molybdenum and tungsten enzymes. 

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