Molecular weight number

The Suzuki aryl-aryl cross-coupling method, adapted to polymers by Schliiter, Wegner and co-workers, made it possible to synthesize solubilized PPPs 6 with a dramatically increased molecular weight (number average up to 100 1,4-phen-ylene units) [17]. 

Some simple global descriptors are molecular weight, number of atoms present in a molecule (e.g., number of chlorine atoms), number of double bonds, etc. Other descriptors represent the ramification of the molecule. Certain descriptors take into consideration the electronic charge on a certain atom, or its polarity. 

There are some very simple heuristic rules concerning cut-offs on molecular weight, number of hydrogen bond donors and acceptors as well as lipophilicity,... 

Oral bioavailability of a drug is primarily dependent upon its rate and extent of drug absorption and systemic clearance. Systemic clearance is primarily composed of hepatic, renal and biliary clearance. The PK properties are in turn directly impacted by the drug s physical properties, such as, log P, log D and pKa. The physical properties are in turn a function of the compound s structure, molecular weight, number of hydrogen bond donors and acceptors, and number of rotatable bonds. Oral bioavailability is the outcome from the dynamic interplay of these factors in the biological system. 

Molecular weights (number average) in the range of 20 000 to 35 000 [88] are achieved in the melt phase and are used for fibre and engineering plastics applications. For some injection moulding and extrusion applications, molecular weights above 40 000 [88] are required. Such high valves are best achieved by SSP. 

Mark-Houwink-Sakurada constant Mass transfer coefficient around gel Fractional reduction in diffusivity within gel pores resulting from frictional effects Solute distribution coefficient Solvent viscosity nth central moment Peak skewness nth leading moment Viscosity average molecular weight Number of theoretical plates Dimensionless number... 

Number - average molecular weight Weight - average molecular weight Number of slices 122 Slice width ... 

The detailed treatment of the molecular weight analysis of polymers is left to other texts. We should be aware that there are two types of molecular weights, number average and weight average. 

Mn molecular weight (number average) (gmol ) polydispersity of the polymer. 

MW molecular weight, number of ligands bound to higher affinity sites, number of ligands... 

Click on the Compute button to calculate physiochemical properties including the number of hydrogen bond acceptors and donors, XlogP (partition coefficient) values, molecular weights, number of rotatable bond, and the Topological Polar Surface Area (TPSA) of compounds. 

Histone Molecular weight Number of amino acid residues acids (%> of total) ... 

Molecular Weight Number of Subunits. Function tea 6 s sre5%v."-iw ... 

Time in h Yield ing Molecular weight Number of polymer chains [N]... 

It is often quite simple to build desirable physico-chemical properties into MCR-derived libraries. Defining drug-likeness in terms of log P, molecular weight, number of H-bond donors and acceptors, rotatable bonds and polar surface area, molar refractivity, MCR methodologies can produce quality drug-like hits for further optimization. 

Lipinski s rules are designed to predict oral availability of compounds that passively diffuse across membranes. Lipinski s rules are based on observations of a database of approximately 2,500 drugs or compounds studied in clinical trials. In general, the compounds could be described structurally with limits on their molecular weight, number of hydrogen-bond donors... 

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