Molecular transcription factor activation

Molecular Transcription Factor Activation in the Cell Nucleus... 

Hai T, Hartman MG (2001) The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors activating transcription factor proteins and homeostasis. Gene 273( 1 ) 1-11... 

Clock gene and transcription factor with histone acetyl-transferase (HAT) activity that (in complex with BMAL1) constitutes a positive limb of molecular circadian oscillators. 

In the case of liganded NRs, ligand binding is the first and ciucial molecular event that switches the function of these transcription factors from inactive to active state by inducing a conformational change in the LBD of the receptor (Fig. 1). This specific conformation allows the second step of NR activation that corresponds to the recruitment of coregulatoiy complexes, which contain chromatin-modifying enzymes required for transcription. The transcriptional coactivators are very diverse and have expanded to more than hundred in number. These include the pi 60 family of proteins,... 

In summary, the apparent redox modulation of lycopene certainly affects two important redox sensitive transcription factors at higher concentrations of lycopene. However, electrophilic lycopene oxidation products cannot be ruled out as the major activators and the activation may be due to specific molecular interactions. 

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