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Molecular strategies development

There are two approaches to analytical evaluation of OBOC libraries analysis of compounds from individuals bead [51,60] and analysis of mixtures of compounds detached from multiple beads [61, 62], It should be mentioned that analysis of mixtures from OBOC libraries is quite different from that described in section Analysis of Libraries Synthesized in the Format of Small Mixtures of 4-12 Compounds per Mixture. In the mixture of compounds cleaved from a few beads, which are randomly picked for analysis from the OBOC library, the structures of components of the mixture are unknown. Consequently, it is not possible to apply the strategy developed for the analysis of mixtures synthesized in spatially addressed format, which is based on information about the structures of components of each mixture. In the case of OBOC libraries, analysis of only very large mixtures is meaningful when the theoretical distribution of molecular weights within the whole library is compared with that experimentally observed [61, 62], The focus of this section is on characterization of OBOC libraries through analysis of individual beads. [Pg.261]

The literature on applications of NMR to problems in molecular biology now encompasses several thousand entries, and space limitations preclude a complete exposition of the subject in this article. Amino acids, peptides, proteins, nucleic acids and their constituents, polysaccharides, phospholipids, membranes, and a large range of biologically active compounds have been extensively studied by NMR. The reader interested in doing research in this field will find it necessary to consult a more extensive treatise (see, e.g.. Refs. 60, 61). Our aim here is to give only a brief introduction to the types of problems that have been studied and an outline of the methods and strategies developed for this purpose. [Pg.39]

Figure 4. One-pot strategies developed to incorporate a second transition metal while achieving full detemplation. (A) Use of catalytic amounts of Fe, whUe the second transition metals is present in stoichometric levels. (B) Explanation why the beforementioned concept does not work. The transition metals catalyses very fast the molecular splitting of H2O2. (C) Two-step and one-pot approach based on detemplation (ppm-level Fe) and subsequent M-exchange. Figure 4. One-pot strategies developed to incorporate a second transition metal while achieving full detemplation. (A) Use of catalytic amounts of Fe, whUe the second transition metals is present in stoichometric levels. (B) Explanation why the beforementioned concept does not work. The transition metals catalyses very fast the molecular splitting of H2O2. (C) Two-step and one-pot approach based on detemplation (ppm-level Fe) and subsequent M-exchange.
The molecularly imprinted copolymer of 2-hydroxyethyl methacrylate (HEMA) and p-CyD-coupled HEMA was synthesized in chloroform to study its interaction with a pair of steroids cholesterol and testosterone [42]. The molecularly imprinted copolymer was found to absorb the print molecule several times better than an imprinted poly HEMA. Asanuma et al. [44] concluded that cholesterol binding by the HEMA polymer was not due to CyD inclusion because no inclusion of CyD to cholesterol can form in chloroform. Another strategy developed for imprinting using CyD elements is the vinyl CyD (Table 1 and 10.3(A)), which has been successfully applied for imprinting antibodies, oligo-peptides [45], and vancomycin [46[. [Pg.292]


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Development strategies

Molecular development

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