Molecular recognition and binding in chemical biology

Essentials of Chemical Biology Andrew Miller and Julian Tanner 2008 John Wiley Sons, Ltd 

The immune system can seem impossibly complex and indeed the study of the immune system (immunology) is without doubt one of the most complex arenas of biology. 

2 Theoretical framework for molecular recognition and binding events 

Water hydration and counter-ion solvation of biological macro molecules considerably alter the translational and rotational dynamics ofbiological macromolecules. The effect can be correlated with a number of different solution properties of a given biological macromolecule such as the hydrated volume Vh- The term Vh is given by 

In the case of the translational frictional forces opposing translational motion, there are two extremes known as the stick boundary condition (strong intermolecular interactions) and the slip boundary condition (negligible intermolecular interactions) that are characterised by the following two basic equations ((7.2) and (7.3) respectively)  

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