Molecular recognition and binding

McLendon, G. Control of Biological Electron Transport via Molecular Recognition and Binding The Velcro Model. Vol. 75, pp. 159-174. 

Molecular recognition and binding is the first step in protein electron-electron transfer. The foregoing data suggests that for the prototypical cyt c ccp system, this binding does not involve specific lock and key recognition, but rather involves complementary sticky patches of protein surfaces (rather like two pieces of velcro adhesive). 

The key region of a drug that is critical for molecular recognition and binding is which of the following ... 

Of course, for many host-guest systems the distinetion between structural and electronic effects is not necessarily clear cut. It is the subtle interplay between both the nature and shape of the respective potential energy surfaces of the two (or more) molecules in a host-guest system that will control both molecular recognition and binding strength. 

As soon as molecular recognition and binding occurs, a shift in the resonance frequency of the crystal is induced. The frequency shift can be easily measured and - as long as the Sauerbrey conditions are fulfilled - interpreted in terms of mass increase. It is the strength of the technique to provide label-free, mass-sensitive detection of the binding reaction at the crystal surface in real time. 

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