Molecular pharmacology binding, pharmacological

De Matters, R (1974). Covalent binding of snlphnr to microsomes and loss of cytochrome P450 dnring oxidative desnlphuration of several chemicals. Molecular Pharmacology 10, 849. 

Lees-Miller, J.P., Duan, Y., Teng, G.Q. and Duff, H.J. (2000) Molecular determinant of high affinity dofetilide binding to hERGl expressed in Xenopus oocytes involvement of S6 sites. Molecular Pharmacology, 57, 367-374. 

Bednarczyk, D., Ekins, S., Wikel, J.H. and Wright, S.H. (2003) Influence of molecular structure on substrate binding to the human organic cation transporter, hOCTl. Molecular Pharmacology, 63, 489-498. 

Table 4 Binding affinities of p-selective opioid analgesics at recombinant human opioid receptor membranes expressed in CHO-K1 or HEK293 cells (Grunenthal, Dep. of Molecular Pharmacology).

To develop highly potent, selective, and efficacious delta agonists of potential therapeutic value, the Molecular Pharmacology Department at AstraZeneca R D Montreal has established and implemented binding and functional assays for all three human opioid receptors [11]. These assays were used to provide in vitro pharmacological data to support the design, synthesis, and analysis of newer generations of delta selective compounds. In the... 

Harvey S, Hayer S (1993) Parathyroid hormone binding sites in the brain. Peptides 14 1187-1191 Hata AN, Zent R, Breyer MD, Breyer RM (2003) Expression and molecular pharmacology of the mouse CRTH2 receptor. J Pharmacol Exp Ther 306 463-470 Haulica I, Neamtu C, Stratone A, Petrescu G, Branisteanu D, Rosea V, Slatineanu S (1986) Evidence for the involvement of cerebral renin-angiotensin system (RAS) in stress analgesia. Pain 27 237-245... 

The only compound in this group whose fate In the body has been studied to a moderately satisfactory extent Is atropine. Some Information on the metabolic fates of B- ulnuclldinyl benzllate and of dlethylamlnoethyl benzllate Is available (193, 219), but It does not account completely for all parts of the molecules. The binding of 3-qulnuclldlnyl benzllate to nerve cells (193,194) and to organelles from such cells (195) has been studied, but no detailed studies, of Its detoxification, pharmacokinetics, and molecular pharmacology have been found for use In this review. Little or no Information on the biochemical aspects of the activities of the anticholinergic compounds surveyed here has been found. Whether such Information exists In literature that has been withheld from consideration for this survey Is unknown. 

Nony PA and Schnellmann RG. Interactions between collagen IV and collagen-binding integrinsin renal cell repair after sublethal injury. Molecular Pharmacology 60 1226-1234,2001. 

Martin, C., Berridge, G., Higgins, C.F., Mistry, P., Charlton, P. et al. (2000) Communication between multiple drug binding sites on P-glycoprotein. Molecular Pharmacology, 58, 624—632. 

Communication between multiple drug binding sites on P-glycoprotein. Molecular Pharmacology, 58, 624—632. 

A main topic in molecular pharmacology deals with the interaction between a receptor molecule and an agonist, either alone or in the presence of a competing antagonist. In a simple case, one molecule of agonist binds reversibly to a receptor... 

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