Molecular genetics detecting defects

Gibson, K.M., Ugarte, M., Fukao, T. et al. (2000) Molecular and enzymatic methods for detection of genetic defects in distal pathways of branched-chain amino acid me-... 

In addition to custom design of photonic proteins, which normally requires site-specific modifications at particular internal residues, TRAMPE can be used to incorporate photonic moieties at nonspecific positions, such as at random lysine residues or only at the N-terminal position of a protein. This approach can be useful in the fields of gene expression, proteomics, and even medical molecular diagnostics. For example, fluorescent labels can be used to monitor in vitro or even in vivo expression of proteins, to build arrays of proteins with which to detect specific protein-protein or drug-protein interactions, and even to detect genetic defects, which are expressed on the protein leveL... 

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