Molecular fields field-based similarity indices

Field-based similarities are usually evaluated by the cosine or correlation function similarity measure employed initially by Carbo and co-workers (67) to compute molecular similarities based upon quantum mechanical wavefunctions. Such a measure, which is usually called a Carbo similarity index, is given by... 

Statistical characteristics of CMF models obtained for these data sets were compared with the same characteristics built for corresponding data sets using the common 3D-QSAR methods, CoMFA (Comparative Molecular Fields Analysis) [18] and CoMSIA (Comparative Molecular Similarity Index Analysis) [24], based on the use of molecular fields. Data on CoMFA and CoMSIA models were taken from Ref. [25]. 

---