Molecular Field Topology Analysis MFTA

In a sense, MFTA may be viewed as a topological analogue of the CoMFA approach. 

Each of these steps is discussed in more detail in the following sections. 

One of the advantages of the MFTA approach is the support of the open descriptor set that can be modified or extended to take into account the specific features of a problem. The currently available descriptors can provide an adequate description of the major types of ligand-biotarget interactions  

In each particular problem, only a subset of the available descriptors should be used that reflects the factors important for the activity in question. 

The descriptor matrix formed by the uniform descriptor vectors for all the training set structures, as well as the experimental activity values, serves as the source data for the statistical analysis and construction of the QSAR model. 

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