Molecular design pharmacodynamics

Includes herbal medications whose pharmacodynamic parameters have been delineated at the molecular level Provides clinical materials, pharmacological concepts, and ancient wisdom about appropriate usage of drugs Presents state-of-the-art and newly designed diagrams to provide an account of how these medications work... 

When designing a dmg to be a cholinergic agonist, selectivity is highly desirable but not a simple term, as therapeutic candidates should be selective for the cholinergic receptor among other neurological receptors, selective for nicotinic or muscarinic, or selective for spedfic subtypes or tissue types. Selectivity could be achieved on the pharmacodynamic level, where the stmcture of the dmg molecule makes it more active at one receptor than another, or on the pharmacokinetic level where the molecular stmcture of the dmg makes it more available to spedfic tissues. Equally important, the new stmcture should retain ACh s activity (see Box 16.1). 

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