Protozoa molecular biology

Gall, J. G., ed. (1986) The Molecular Biology of Ciliated Protozoa, Academic Press, Orlando, Florida... 

Normore, W. M. (1976). Guanine-plus-cytosine (G+C) composition of the DNA of bacteria, fungi, algae and protozoa. In CRC handbook of biochemistry and molecular biology, 3rd edn, Nucleic acids, vol. 2., ed. G. D. Fasman, pp. 65-235. CRC Press Boca Raton, FL. 

The term molecular mimicry (34), is difficult to define, in part, because it does not represent a single concept (35,36). In this review, we use the term in the sense of adaptive molecular mimicry as proposed by Roger Hall in 1994 (37). According to Hall, adaptive molecular mimicry means that a parasite (bacteria, fungi, virus, helminth, protozoa) molecule mimics a host molecule for a biological reason, and the homologous functional structure resides in a parasite molecule which is otherwise dissimilar to... 

Guaianohdes have also been intensively examined toward protozoa like members of the genera Trypanosoma (sleeping sickness), Leishmania (leishmaniasis), and Plasmodium (malaria) only studies that also tested cytotoxic activity are considered here. In all cases, an antiprotozoal activity correlates positively with cytotoxicity, and the major determinants for activity are a,p-unsaturated carbonyl residues. Certain compounds are considerably more toxic against protozoa than against mammalian cells and vice versa. A comparative QSAR analysis has been undertaken, and both activities were found to depend mainly on the same structural elements and molecular properties. The observed variance in the biological data can maybe be explained by the positioning of the various molecules in the active site [63-65]. 

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