Modulation of Insulin Secretion via Adenylate Cyclase and Phospholipase C PLC

4 Modulation of Insulin Secretion via Adenylate Cyclase and Phospholipase C (PLC) [Pg.92]

Similar to other tissues, insulin-producing cells possess an adenylate cyclase-cAMP system including stimulatory and inhibitory G-proteins and phosphodiesterases. [Pg.92]

Inhibition of the adenylate cyclase system is also derived from somatostatin and a-adrenergics which interact with the inhibitory receptor of this enzyme system. [Pg.93]

The role of metabolism and/or metabolic products of membrane phospholipids under the influence of PLC and PLA2 has been reviewed by Henquin (1985) and Morgan and Montague (1992). [Pg.93]

Activation of PLC generates diacylglycerol (DAG) and inositol trisphosphate (Ins(l,4,5)/ 3). In contrast with many cells, islet PLC may also be directly [Pg.93]

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