Modified light delivery systems

Since the OTC trial, there has been rapid advancement in vector development with marked improvements in the safety (and efficacy) of new viral delivery systems. There is also a better understanding of the immunological responses to gene therapy vectors. The adverse events in the SCID trial are more recent. They appear to be a likely result of the choice of vector (retrovirus) and the ex vivo selection strategy used to modify the affected stem cells of the SCID patients. The risk benefit ratio for gene therapy treatment of these children is still deemed favorable in light of the fact that without treatment, they would not be alive. 

Size Exclusion Chromatography (SEC) is widely used technique polymer characterization. The standard configuration of a SEC apparatus consists of three parts (/-5), viz., a solvent-delivery system (equipped widi an injection port), the columns, and a differential refractive index (RI) detector. This basic configuration can be modified by adding an additional detector, either in series or in parallel to the RI detector (J-5). The second detector can be a viscometer (2), a concentration detector (3), an UV detector (4) or a Light Scattering (LS) device (5),... 

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