Modified Bucherer-Bergs Reaction

Despite the wide scope and potential of the multicomponent (MC) Bucherer-Bergs reaction, this procedure exhibits a limitation since only changes in the structure of the corresponding ketones can be addressed, leading to variations in the skeleton of the final hydantoin [31]. However, with the aim in mind of increasing the utility and scope of 

Classical Bucherer-Bergs reaction (4-CR, one point of diversity) 

SCHEME 10.9 Synthesis of hydantoins 2 using organolithium compound and Grignard reagents. 

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C. Montagne, M. Shipman, Synlett 2006, 2203-2206. Modified Bucherer-Bergs reaction for the one-pot synthesis of 5,5 -disubstituted hydantoins from nitriles and organometallic reagents. 

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