Model-robust orthogonal design

Table 2. Design indices for 16-run EC-optimal orthogonal designs over four model spaces of Li and Nachtsheim (2000) (for model-robust orthogonal designs), Bingham...

Model-robust orthogonal designs Model-robust parameter designs Addelman A Sun h ... 

Table 3. Summary of properties of 20-run model-robust orthogonal designs pq denotes the percentage of designs for which ECq = 100% ave( C ) is the average ECq over all designs with / factors ...

For the clearance of enveloped and non-enveloped viruses, today s requirements ask for an orthogonal combination of methods that are based on the different physical principles of removal and inactivation, and are complementary to each other [165]. Virus filtration and solvent/de-tergent treatment are state of the art for removal and inactivation [166, 167]. Partitioning steps are considered less robust, as they are somewhat influenced by the actual process conditions. In any case, scaled-down models must be designed... 

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