Mode fipronil

Cyflumetofen [198] is an experimental acaricide/miticide for use in vegetables and fruits. Pyriprole and pyrafluprole are two experimental insecticides introduced by Nihon Nohyaku and related, both in chemistry and mode of action to the highly successful insecticide fipronil. Fipronil acts at the GABA receptor to block the chloride channel. 

Soon after the development of fipronil was announced in 1992 [8], its mode of action as an NCA of GABA-gated chloride channels was published. Fipronil and other insectiddal phenylpyrazoles were observed to cause symptoms in house flies and mice that were similar to those of the known GABA antagonists dieldrin... 

Pyroles and phenylpyrozoles. The pyroles such as chlorfenapyr act as metabolic toxins and work by uncoupling oxidative phosphorylation in the mitochondria. In contrast the phenylpyrozole, fipronil has a mode of action similar to the cyclodiens (e.g. aldrin) and acts as an axonic poison. 

This study focuses on the development of a quick method for the extraction and detection of fipronil residues and its main three metabolites in Hawaiian soil (Helemano series) and cotton gauze swipe samples. Pressurized fluid extraction was used for its ease of use and automated state, its reduction in organic solvent consumption, and time saving interests. Gas chromatography-mass spectrometry (GC-MS) in selected ion monitoring mode was enq )loyed for the detection and quantiflcation of the extracts. The extraction method was optimized for the Hawaiian soil for the simultaneous extraction of the four confounds, and was then applied to soil and cotton gauze sanq)les collected from Maui, Hawaii, after a residential spray of fipronil. 

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