Modafinil Dextroamphetamine

Wesensten, N. J., Killgore, W. D. Balkin, T. J. (2005). Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation./. Sleep Res. 14 (3), 255-66. 

Comparisons of modafinil with agents that have proven effective in narcolepsy, including methylphenidate, pemoline, and dextroamphetamine, are needed to clarify its relative safety and efficacy, and place in therapy... 

Pigeau et al. (226) assessed the usefulness of modafinil for preventing fatigue-related declines in alertness and performance and for recovering from decrements that had already occurred. Forty-one soldiers were subjected to 64 hr of continuous wakefulness during which 300-mg doses of modafinil, 20 mg doses of dextroamphetamine, or placebo were administered at 17.5, 47.5, and 57.5 hr. Compared to placebo, both modafinil and amphetamine suppressed the amplitude... 

Wong YN, Wang L, Hartman L, Simcoe D, Chen Y, Laughton W, Eldon R, Markland C, Grebow P. Comparison of the single-dose pharmacokinetics and tolerability of modafinil and dextroamphetamine administered alone or in combination in healthy male volunteers. J Clin Pharmacol 1998 38(10) 971-8. 

Hellriegel ET, Arora S, Nelson M, Robertson P Jr. Steady-state pharmacokinetics and tolerability of modafinil administered alone or in combination with dextroamphetamine in healthy volunteers. J Clin Pharmacol 2002 42(4) 450-60. 

Other stimulants used in treatment of autism include dextroamphetamine, dexmethylphenidate, modafinil, and pemoline (Oswald and Sonenklar, 2007). Aside from a small, early trial of dextroamphetamine that reported poor results (Campbell, 1975), these agents have not been evaluated in controlled trials with ASD subjects. 

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