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Mixed-type prodrugs

In some cases, the design of mixed-type prodrugs can be advantageous, as illustrated in the following three examples. [Pg.740]

FIGURE 36.40 Disulfide thiamin prodrugs as example of mixed-type prodrugs. ... [Pg.741]

A Water-soluble taxol prodrugs 572 B Existence of mixed-type prodrugs 580... [Pg.561]

Fig. 33.40 Trigonelline amides (or esters) as examples of mixed-type prodrugs. Fig. 33.40 Trigonelline amides (or esters) as examples of mixed-type prodrugs.
B. Existence of mixed-type prodrugs Difficulties and Limitations Conclusion... [Pg.963]

A new type of prodrug of d4T, 200, has been prepared. Such compounds, and the analogous ddT species, degrade hydrolytically under physiological conditions without the need for an enzyme. AZT and ddT derivatives 201 (R=Me, Ph) have also been prepared. Hydrolysis of the carboxylic ester leads to rapid release of the 5, 5 -dinucleosidyl phosphate by a process of neighbouring group catalysis, with a mixed phosphoric-carboxylic anhydride as an intermediate. ... [Pg.294]

See other pages where Mixed-type prodrugs is mentioned: [Pg.721]    [Pg.740]    [Pg.741]    [Pg.580]    [Pg.721]    [Pg.740]    [Pg.741]    [Pg.721]    [Pg.740]    [Pg.741]    [Pg.580]    [Pg.721]    [Pg.740]    [Pg.741]    [Pg.331]    [Pg.2700]   


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Mixed types

Prodrug

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