Mixed-regimes, first-order transitions

Recently, the unsatisfying situation that either zero-order kinetics or first-order kinetics must be obeyed in the experiments prompted new simulations that include the transition region from first-order to zero-order kinetics. Burchardt et al. [81] simulated approach curves and provided detailed guidelines for the conditions under which a treatment with first-order kinetics is appropriate. Comut et al. [82] calculated analytical approximations for the conditions of zero order with respect to the substrate and a mixed regime with respect to the mediator. It is also evident that the reaction order could vary laterally along the sample surface and therefore a special treatment would be required in that case. 

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