Mitragyna speciosa

Methoxy-3,4,5,6-tetradehydrocorynantheol (286), 3,4,5,6,18,19-Hexade-hydroochropposinine (287), 3,4,5,6-Tetradehydrositsirikine (288), Alstonine (289), the no-name-alkaloid (290) (Mitragyna speciosa) (98T8433), 3,4,5,6-Tetradehydropalicoside (291) and its methylester which were isolated recently from Strychnos mellodora (99P1171), Serpentine (292), and Serpentinine (293) are known representatives of this class of alkaloids. 

About 120 species of plants classified within the family Rubiaceae are used in traditional medicine of Asia and the Pacific, of which, Mitragyna speciosa has been used throughout Southeast Asia, especially in Thailand and Borneo, as an intoxicant. The leaves are chewed alone or mixed with betel, or else prepared for smoking like opium, and its use is legally prescribed in Thailand. 

Uncaria rhynchophylla Miq. (57). The N-oxide of hirsutine (58) has been found in Uncaria tomentosa DC. (55), and 3-isopaynanthiene (59) has been isolated from Mitragyna speciosa Korth. (58). 

Epiallo Series. Previously, only speciociliatine (63) was known as a cory-nantheine-type alkaloid having an epiallo skeleton. Two new alkaloids in this series were isolated during the last decade, i.e., epiallocorynantheine (64) from Uncaria attenuata (59) and 3-isocorynantheidine (65) from Mitragyna speciosa Korth. (58). 

Horie, S., Koyama, F., Takayama, H., Ishikawa, H., Aimi, N., Ponglux, D., Matsumoto, K. and Murayama, T. 2005. Indole alkaloids of a Thai medicinal herb, Mitragyna speciosa, that has opioid agonistic effect in ginea-pig ileum. Planta Medica, 71 231-236. 

Mitragyna speciosa Korth. [leaves, stem Rubiaceae bark, root bark mature, young plants]... 

Echinacea spp. (Asteraceae), Cistanche deserticola (Orobanchaceae) [stem] Mitragyna speciosa (Rubiaceae),... 

Chemistry and pharmacology of analgesic indole alkaloids from the Rubiaceous plant, Mitragyna speciosa 04CPB916. 

From a South-East Asian plant Mitragyna speciosa. Related to the coffee plant. Alkaloids include mitragynine similar to ibogaine. Euphoria, vomiting, vertigo, arrhythmias, twitching. The dried leaf is called Kratom and is smoked, the distillate is called Mambog and is imbibed. 

Chemical studies on the analgesic indole alkaloids from the traditional medicine (Mitragyna speciosa) used for opium substitute 00YZ959. 

Specionoxeine (mp 225°) and isospecionoxeine (mp 179°) are two isomeric oxindole alkaloids of C23H2SN2O5 constitution isolated from Mitragyna speciosa (27). The similarity of their spectral data and those of other oxindoles indicates that the two alkaloids possess a rhyncho-phylline-type structure and carry an extra methoxyl group on the aromatic ring. 

Three new, interconvertible isomers of speciofoline have been isolated from leaves of Mitragyna speciosa, and the stereochemistry of all four bases has been elucidated. They constitute the four allo-epiallo isomers of the oxindole analogue of 9-hydroxycorynantheidine mitrafoline is the alio-A isomer (80), isomitrafoline is allo-B (81), isospeciofoline is epiallo-A (82), and speciofoline is epiallo-B (83). New studies of the isomerization of isorotundifoline [normal B isomer of (83)] have revealed the formation of a transient product identified as 3-epi-isorotundifoline [pseudo-B isomer of (83)] there is, however, no evidence to suggest that it is a... 

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