Mitomycin adverse effects

The efficacy and adverse effects of various alternative treatment regimens for carcinoma in situ of the bladder have been compared with those of instillation of BCG in 21 patients. All were treated initially with intravesicular instillations of Keyhole-Limpet Hemocyanin (first course 20 mg weekly for six weeks second course 20 mg monthly for 1 year or bimonthly for 2 subsequent years). Patients who did not respond to two courses were treated with regular instillations of BCG Connaught strain 120 mg. Eleven patients were free from tumor tissue after the first or second course of Keyhole-Limpet Hemocyanin. Ten patients had to have a cystectomy because of persistence or progression of carcinoma after hemocyanin or hemocyanin with subsequent BCG. However, instillations of BCG caused severe dysuria in 60% and fever in 40% of patients, whereas hemocyanin treatment had only minor adverse effects (28). Combined therapy with mitomycin C and BCG was more effective in 28 patients with carcinoma in situ of the bladder than mitomycin alone (29). Compared with... 

Mitomycin is an alkylating agent that is used intravenously to treat upper gastrointestinal and breast cancers and by direct instillation to treat superficial bladder tumors. Its main adverse effects are thrombocytopenia and leukopenia. Rare but severe adverse effects are hemolytic-uremic syndrome, pneumonitis, and cardiac failure. 

Myelosuppression is among the adverse effects of aclarubicin. The concurrent use of other drugs with similar myelosuppressant actions may be expected to have additive effects. Previous treatment with nitrosoureas (not specifically named) or mitomycin has been shown to increase the severity of the myelosuppression. 4... 

Pacific Northwest.) Encyclopedic references comment that the antibiotics doxorubicin, daunorubicin, bleomycin, mitomycin, and dactinomycin are all antineoplastic or anticancer agents, but are mostly too toxie for antibiotic use (and perhaps are too toxic to be used as anticancer agents, a ease again of adverse side effects). 

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