Mitochondrial Permeability Transition in Spinal Cord Injury

10 Mitochondrial Permeability Transition in Spinal Cord Injury 

Mitochondria are the powerhouse of neural cells. They play a critical role in initiating both apoptotic and necrotic cell death (Fig. 4.6). By maintaining ratios of ATP ADP that thermodynamically favor the hydrolysis of ATP to ADP + Pi, they 

Cyclosporin A (CsA), a potent immunosuppressive drug, blocks mitochondrial permeability transition (mPT) through its interactions with matrix cyclophilin D. Binding of cyclophilin D is increased in response to oxidative stress and some thiol 

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