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Misoprostol adverse effects

Labor and delivery - Misoprostol can induce or augment uterine contractions. A major adverse effect of the obstetrical use of misoprostol is hyperstimulation of the uterus, which may progress to uterine tetany with marked impairment of uteroplacental blood flow, uterine rupture (requiring surgical repair, hysterectomy, and/or salpingo-oophorectomy), or amniotic fluid embolism. [Pg.1374]

Adverse effects are uncommon although diarrhea and abdominal cramping in up to 30% of patients may limit its use. Misoprostol should be avoided in pregnant subjects and women of childbearing potential should be advised of adequate contraception as misoprostol may cause miscarriage. Effects on the developing human fetus are not known. [Pg.380]

A major iimitation to the use of NSAIDs is gastrointestinal ulceration and bleeding, particularly in the stomach, due to suppression of protective gastric prostaglandins (PGs). NSAID-induced ulceration. The concomitant administration of the PGEl analogue, misoprostol, is more effective but is expensive and associated with an appreciable incidence of side effects, notably diarrhoea Renal adverse effects... [Pg.135]

Gastrointestinal ulceration may occur less frequently than with some other NSAIDs. A preparation combining diclofenac and misoprostol decreases upper gastrointestinal ulceration but may result in diarrhea. Another combination of diclofenac and omeprazole was also effective with respect to the prevention of recurrent bleeding, but renal adverse effects were common in high-risk patients. Diclofenac, 150 mg/d, appears to impair renal blood flow and glomerular filtration rate. Elevation of serum aminotransferases occurs more commonly with this drug than with other NSAIDs. [Pg.803]

Intramuscular methotrexate 50 mg/m2 followed by intravaginal misoprostol was effective in the induction of first trimester abortion. Adverse events following the administration of misoprostol included nausea (12%), vomiting (8.1%), diarrhea (7.4%), and fevers/chills (3.4%) (4). [Pg.127]

Misoprostol has been used to induce abortions in 150 adolescents (age range 12-17 years) at gestations of 63-84 days (7). They received vaginal misoprostol 800 micro-grams/day to a maximum of three doses. Complete abortion occurred in 84%. Adverse effects were more frequent in these adolescents than in adult women, and included nausea (31%), vomiting (41%), diarrhea (48%), dizziness (19%), headache (17%), a subjective feeling of fever (26%), flushing (16%), and chills (49%). [Pg.128]

Oral misoprostol 400 micrograms has been compared with placebo in the routine management of the third-stage of labor. In this study shivering was a specific adverse effect of oral misoprostol in the puerperium (19 versus 5% RR = 3.69 95% Cl = 2.05, 6.64) (14). [Pg.128]

Khan RU, El-Refaey H. Pharmacokinetics and adverse-effect profile of rectally administered misoprostol in the third stage of labor. Obstet Gynecol 2003 101 968-74. [Pg.133]

Whatever the adverse effects of mifepristone, the risks have to be looked at realistically and compared with those of the alternatives available to a particular woman in particular circumstances. Particularly in rural areas in developing countries, the risks of surgical and non-professional abortion are high, whereas, as has been shown in a study in rural India, a regimen of mifepristone plus misoprostol can be used as effectively and safely, through family planning clinics and country hospitals, as in a European environment (2). [Pg.285]

Various anti-progestogenic routines for the termination of pregnancy continue to be compared. Of 354 women who were given mifepristone 200 mg in the clinic and then sent home with two tablets of misoprostol 200 micrograms to take 48 hours later, 324 (91.5%) had a successful termination (7). The most common adverse effects were pain or cramps (93%) and nausea (67%), followed by weakness (55%), headache (46%), and dizziness (44%). Overall acceptability of the regimen was high 63% of women reported that it was very satisfactory and another 23% found it satisfactory . There were no serious complications and the simplified routine, with a much reduced duration of hospital care, was considered acceptable. [Pg.285]

There has sometimes been reluctance to use higher doses of mifepristone, because of a supposedly greater risk of severe adverse effects. However, in a randomized comparison of a single oral dose of mifepristone (either 200 mg or 600 mg) followed 48 hours later by oral misoprostol 400 pg the two regimens produced identical results as regards the induction of abortion and the incidence of adverse effects (22). [Pg.287]

Withdrawal from the study owing to adverse effects was also more frequent in the misoprostol arm of the OMNIUM study. [Pg.1630]

Lansoprazole 15 and 30 mg/day were more effective than placebo, but not misoprostol 200 micrograms qds, for the prevention of NSAID-induced gastric ulcers in a multicenter, double-blind, placebo-controUed trial in 537 patients without Helicobacter pylori infection who were long-term users of NSAIDs (2). However, adverse effects were significantly more frequent (31% versus less than 20%) and treatment adherence significantly less (71% versus more than 90%) in patients taking misoprostol. The most commonly reported adverse effects in aU groups were diarrhea, abdominal pain, and nausea. [Pg.2001]


See other pages where Misoprostol adverse effects is mentioned: [Pg.156]    [Pg.872]    [Pg.200]    [Pg.220]    [Pg.481]    [Pg.480]    [Pg.610]    [Pg.664]    [Pg.833]    [Pg.847]    [Pg.916]    [Pg.413]    [Pg.914]    [Pg.1316]    [Pg.103]    [Pg.128]    [Pg.128]    [Pg.128]    [Pg.129]    [Pg.131]    [Pg.285]    [Pg.285]    [Pg.286]    [Pg.286]    [Pg.287]    [Pg.220]    [Pg.452]    [Pg.819]    [Pg.961]    [Pg.250]    [Pg.278]    [Pg.172]    [Pg.629]    [Pg.632]    [Pg.1630]   
See also in sourсe #XX -- [ Pg.734 ]

See also in sourсe #XX -- [ Pg.643 , Pg.1696 ]

See also in sourсe #XX -- [ Pg.626 ]




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