Miscellaneous sulphonamide

All these compounds grouped together under miscellaneous sulphonamide diuretics shall be treated individually as under ... 

The HPLC-receptorgram assay combined the advantages of HPLC separation with the multiresidue detection of the Charm II tests. The procedure was tested for identification and quantitation of the most common veterinary drugs at regulatory levels or lower. It was validated for 40 individual drugs from seven antibiotic families 10 /3-lactams, 13 sulphonamides, 8 tetracyclines, 4 macrolides, 3 amphenicols, and other miscellaneous antimicrobials. This procedure combined a simple aqueous extraction and SPE with HPLC fractionation of individual drugs. Final identification and quantitation was achieved with the Charm II test. A drug contaminant could be identified in less then 3 hours (50). 

For further characterisation of oximes, imides and primary sulphonamides see p. 1226 under the miscellaneous neutral and acidic compounds containing nitrogen. 

Despite the interest in, and importance of, sulphonic acids and their salts, osylates and other sulphonate esters, sulphonamides, sulphonyl halides and miscellaneous derivatives such as disulphones, thermochemical data for this class of compounds are disappointingly sparse and often suspect. Thus the data will not be presented in the form of tables, but rather will be discussed one primary reference at a time per subsection. Because the required gas phase data are almost totally absent, we will also not attempt to generate Benson increments1 for groups of interest such as S02(C)(0), as would be part of a thermochemical study of sulphonic acids and their esters but not the isomeric sulphites that contain the SO(0)2 group. As such, this chapter is unlike so many of the other thermochemical chapters in the other volumes of The Chemistry of the Functional Groups series. 

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