Miscellaneous Michael Additions for Indoles

Due to high efficiency and in some cases even enantioselectivity, solid state reactions have recently attracted considerable attention to various types of organic reactions [194-197]. The solid-state Michael reactions between 4-arylidene-3-methyl-l-phenyl-5-pyrazolones 267a-f and indole gave rea- 

Synthesis, structure and conformational behavior of cyclophanes are of interest. Synthesis of a novel chiral cyclophane consisting of indole as one of the core units was achieved [198]. The first bridge of the cyclophane 273 is formed by a conjugate addition of indole (2) to the unsaturated ketone 269. An intramolecular N-alkylation reaction of 271 resulted in the formation of 

Cchair Nchair Cboat Nchair Cchalr Nboat CcboatiNboat 

N-Michael addition of indole to achiral Ni(II) complex 278 led to the synthesis of racemic ct-amino acid 280 [202], The first of the two-step reactions is 

The Diels-Alder reactions of 2- or 3-vinylindoles represent an attractive methodology for the synthesis of many indole alkaloids and annu- 

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