Miscellaneous Considerations

Several important considerations for column preparation and testing do not adequately fit under any of the previous headings. Some are outlined below  

All the relevant statutory and regulatory requirements and company practices for handling the chemicals must be strictly adhered to during commissioning. 

Freezing of water or residual chemicals prior to startup or following a shutdown can damage equipment and introduce hazards because of plugging. Water should be drained from all low point drains at a shutdown. All drains should be checked for plugging. 

If p n ophoric deposits are anticipated, the areeis where these deposits are likely to accumulate shovild be kept wet or oiled upon shutdown. 

When using reusable glassware in the laboratory, crosscontamination (Section 9.7.1) is always a concern 

Once again, the documentation of all procedures conducted and equipment used is critical in terms of supporting the final data. SOPs specific to the laboratory where the solutions were prepared will dictate the exact documentation requirements but, at a minimum, the 

In the discussion on residence time distribution it was mentioned that the RTD of a static mixer tends to be narrower than the RTD of a narrow pipe. However, in addition to the RTD the actual residence times are important as well. Static mixers always add extra volume between the extruder and the die. Therefore, when a static mixer is used, the mean residence time will always increase when the entire extrusion system is considered, i.e., extruder, static mixer, and die. If the static mixer section is long, which it should be to give good mixing, then the increase in mean residence time can be considerable. This should be a concern in thermally less stable polymers. 

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Miscellaneous considerations, including wall-facing details and external drainage are completed. This addresses other possible stability issues. 

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