Minor cluster region

MBR major breakpoint region MCR minor cluster region V variable segments D diversity segments J joining segments C constant region TE transcriptional enhancer... 

Nambiar M, Raghavan SC. Mechanism of fragility at BCL2 gene minor breakpoint cluster region during t(14 18) chromosomal translocation. J Biol Chem. 2012 287 8688-701. 

Ph CML and about one third of the patients with Ph acute lymphatic leukemia (ALL) (van Rhee et al. 1996). In the remaining Ph ALL patients (and a small number of patients with CML), the breakpoints are in the alternative Bcr exons el and e2 (minor breakpoint cluster region, or m-BCR), and the elal fusion mRNA is translated into a 190-kDa protein kinase (pl90BCR-ABL) responsible for the characteristic disease phenotype (Ra-vandi et al. 1999 van Rhee et al. 1996). 

Gold has been used for many years as a minority carrier lifeline controller in Si. As such, it is introduced in a controlled manner, usually by diffusion into transistor structures to decrease the carrier lifetime in the base region in order to increase the switching speed (Ravi, 1981). Conversely, the uncontrolled presence of Au is clearly deleterious to the performance of devices, both because of the increased recombination within the structure and the increase of pipe defects, which can cause shorting of the device. These pipe defects consist of clusters of metallic impurities at dislocations bounding epitaxial stacking faults. 

In order to interpret the Na" " and Cs" " diffusional results in terms of this model, it is assumed that both cations would be able to diffuse readily in both the ionic clusters and interfacial regions. Cesium ion would experience a more tortuous diffusion path compared to sodium ion, and thus would have a smaller measured self-diffusion coefficient. The insensitivity of this diffusion coefficient to increasing water sorption may then be because most of this water serves to increase the size of ionic clusters, which would have a relatively minor overall effect on the diffusion path length. 

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