Minocycline hypertension

The mechanism of minocycline-induced intracranial hypertension may be similar to that postulated for the tetracyclines, which has been shown to be related to reduced cerebrospinal fluid absorption due to an effect... 

Lander CM. Minocycline-induced benign intracranial hypertension. Clin Exp Neurol 1989 26 161-7. 

Monaco F, Agnetti V, Mutani R. Benign intracranial hypertension after minocycline therapy. Eur Neurol 1978 17(l) 48-9. 

A 70-year-old man with hypertension took nifedipine 10 mg bd and 3 months later developed a pruritic eruption on his back, which spread to cover his trunk, limbs, face, and scalp, with involvement of the mouth. His skin deteriorated after the dosage of nifedipine was increased to 20 mg bd 1 year later. Antibodies to the 230 kDa pemphigoid antigen were detected in his serum. His skin improved considerably after withdrawal of nifedipine and the use of topical steroids and oral minocycline. 

Lubetzki C, Sanson M, Cohen D, Schaison-Cusin M, Lhermitte F, Lyon-Caen O. Hypertension intracrenienne benigne et minocycline. [Benign intracranial hypertension and minocycline.] Rev Neurol (Paris) 1988 144(3) 218-20. 

Numerous drugs have been associated with the development of vasculitis (ten Holder et al. 2002 Cuellar 2002). For example propylthiouracil is associated with cutaneous, renal, and pulmonary vascultis aUopurinol is associated with cutaneous, renal, and hepatic vasculitis hydralazine is associated with cutaneous, renal, and pulmonary vascultis and isotretinoin is associated with cutaneous, renal, pulmonary, and gastrointestinal vascultis (Cuellar 2002 ten Holder et al. 2002). Systemic polyarteritis nodosa, a vasculitis with involvement of small- and mediumsized renal arteries, has been described following minocycline use (Cuellar 2002). Patients may present with hematuria, proteinuria, reduced renal function, and hypertension. Hydralazine, propylthiouracil, aUopurinol, and peniciUamine have been implicated in the development of antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis (Choi et al. 2000). Patients exposed to these drugs... 

Fraser C, Biousse V, Newman C. Minocycline-induced fulminant intracranial hypertension. Arch Neurol 2012 69(80) 1067-70. 

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