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Mimosine complexes

Logi i — 10.2 for the complex of mimosine (226) shows that this mimosine complex is, like the and complexes of this ligand,... [Pg.200]

The condensation of 3,4-HP with deoxyribonucleotide results in a unique metal-binding nucleotide (55) which can be incorporated into an oligonucleotide chain. This ohgonu-cleotide has higher thermostability in the presence of Cu(II) compared with an A-T pair, wherein Cu(II) binds to 3,4-HP from each strand to form a double helix (56). li en the Fe(II)-mimosine complex is introduced to plasmid DNA, cleavage of the supercoiled form is observed in the presence of H2O2 and dithiothreitol. The observations described in this section point to mimosine (9) and its analogues as the leads for further exploration of their potential application as metal chelators and therapeutics. [Pg.602]

The effects of leucaena and mimosine on nonruminants can be reduced to some extent by diet supplementation with ferrous sulfates. Mimosine forms a complex with iron, which is excreted in the feces. Zinc supplementation has reduced the toxicity in cattle and it is believed that copper and zinc ions bind more strongly to mimosine than most other amino acids. [Pg.57]

The speciation and stabihty constants of the Cu(n), Ni(II), Zn(II) and VO(II) complexes of mimosine (9) were determined . The Cu(II) and VO(II) complexes adopt a coordination chemistry analogous to the those of maltol (discussed below). The Zn(II) complex of the deprotonated mimosine analogue 48 has a 1 2 distorted square-pyramidal structure with trans configuration and a water molecule at the apex (49) . Pb(II) forms a 1 2 complex with 48, which further interacts with one enolate of an adjacent Pb(II) center via Pb-0 bridges (2.64 A) to yield a dinuclear Pb complex (50). Vanadate (with a -1-5 oxidation state on V) forms with 48 the 1 1 [V02(48 )(0H)(H20)] and 1 2 [V02(48 )2] complex anions, as shown by potentiometry, cyclic voltammetry and NMR and EPR spectroscopies, with V NMR peaks at —502 and —476 ppm, respectively, similar to the maltol complexes (peaks at —509 and —496 ppm) discussed in the next section. [Pg.600]

The 3-hydroxy-4-pyridinone moiety in the mimosine drug family is responsible for metal binding (Section ni.B.l.c). The structure of a number of such complexes was determined by X-ray crystallography. The 3 1 complexes of 48 with Fe(IIt) , Al(Itl), Ga(III)... [Pg.615]


See other pages where Mimosine complexes is mentioned: [Pg.188]    [Pg.188]    [Pg.187]    [Pg.219]    [Pg.421]    [Pg.503]    [Pg.938]    [Pg.600]    [Pg.601]    [Pg.612]    [Pg.620]    [Pg.660]    [Pg.661]    [Pg.5811]    [Pg.6050]   
See also in sourсe #XX -- [ Pg.187 ]




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