MIM-EPI

FIGURE 15.3 (a) MRM and (b) MIM scan modes on QTRAP. MRM can be operated either MRM-only for quantification or pMRM—EPI for metabolite detection and MS/MS spectra recording. MIM is mainly used as MIM-EPI in either a targeted or screening method for metabolite profiling and identification. 

FIGURE 15.5 Work flow of metabolic soft spot determination using EMS-EPI or MIM-EPI EIC, extracted ion chromatography PIF, product ion filter NLF, neutral loss filter. 

FIGURE 15.6 Detection of ritonavir metabolites in rat hepatocytes by the 4000 QTRAP. a) TIC of EPI from EMS EPI Scan, b) TIC of EPI from MIM-EPI scan with 24 MIM transitions, (c) TIC of EPI from MRM—EPI scan with 22 transitions. (survey monitored either 22 MRM transitions or 24 MIM transitions. [Reprinted from Yao et al. (2008) with permission of John Wiley Sons.]... 

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