Milestones of Progress

Associated with the segment of complex systems that are identified with drug research are the conceptual and technical advances that have illuminated these systems and that have brought us to our present state of understanding and skill. We identify some of these and show in Fig. 1 their relationship to some complex systems in our realm of interest. 

Each of the advances in Fig. 1 has its roots in an effort to describe the ingredients of a complex system, and is built upon the Newtonian concept of reduction to parts in an effort to understand the whole system. It is to this 

Newtonian view of the world that we now turn our attention before introducing the post-Newtonian view. 

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Figure 10. Milestones of progress for the enantioselective hydrogenation of MEA imine (requirements ee 80%, tof >10 000 h, s/c >50 000)...

There are bound to be milestones of progress. Shall we, on these occasions, receive the news immediately Can we have assurances that the Declassification Committee will not cause any more delays of future announcements It seems to be a committee with incredible power. Few people are aware of its composition, or when it meets. No one knows to what extent it has been classified and declassified, but is it not proving a very strong barrier between Harwell and the Government ... 

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