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Migraine treatment drugs

Zhang L, HayJW. Cost-effectiveness analysis of rizatriptan and sumatriptan versus Cafergot in the acute treatment of migraine. CNS Drugs. 2005 19 635-642. [Pg.286]

As mentioned previously, one of the major benefits of nasal drug delivery is the rapid onset of action (tmax)- Migraine treatment takes advantage of this fact. Compared to the orally taken tablet, tmax is much shorter. The neurosecretory hormone melatonin, which is used widely against jetlag, shows a very impressive time profile when administered as a nasal spray. The peak levels of melatonin after nasal administration appear to be 50 times higher than after oral administration. [Pg.1208]

However, this route of administration is eminently logical, in several circumstances. For the acute treatment of migraine, oral drugs are often vomited (sumatriptan). For treating acute asthma, children often cannot use an inhalational device properly (theophyliine). For perioperative antibiotics, patients are often nil by mouth (metronidazole). For inflammatory bowel disease and proctitis, this is simply a topical administration. [Pg.58]

The use of suppositories is probably one of the clearest examples of cross-cultural differences in the approach to pharmaceuticals. A surgeon on a famous ocean liner has commented that Part of the problem of stocking one s pharmacy is that one needs three times as many drugs as when working on land tablets for the Brits, shots (injectables) for the Yanks, and suppositories for the French However, the route of administration is eminently logical, e.g. for the acute treatment of migraine, where drugs are often vomited. [Pg.52]

The substitution pattern of the first example is particularly important as the neurotransmitter serotonin is an indole with a hydroxyl group in the S-position, and many important drugs follow that pattern. Sumatriptan (marketed as Imigran, the migraine treatment) is an analogue of serotonin, whose synthesis starts with the formation of a diazonium salt (Chapter 22) from the aniline shown below. Nitrosation gives the diazonium salt, and reduction with SnClj and HCl returns the salt of the phenylhydrazine. [Pg.777]

Paroxysmal Disorders. Migraines are paroxystic, intense hemicranial pain episodes, accompanied by vomiting and light sensitivity. The cause of these episodes is still unclear. Acute treatment of migraine employs drugs such as sumatriptan and ei otamine, while prophylactic therapy uses various agents such as propranolol, verapamil, amitriptyline, and valproate. [Pg.1290]

Among the indole derivatives which have found use as drugs are indo-methacin, one of the first non-steroidal anti-inflammatory agentsfll], sumatriptan, which is used in the treatment of migraine headaches[12] and pindolol[13], one of the p-adrenergic blockers. [Pg.1]

These dm are primarily used in the treatment of hypertension (see the Summary Drug Table Adrenergic Blocking Drugs also see Chap. 39) and certain cardiac arrhythmias (abnormal rhythm of the heart), such as ventricular arrhythmias or supraventricular tachycardia They are used to prevent reinfarction in patients with a recent myocardial infarction (1—4 weeks after MI). Some of these dm have additional uses, such as the use of propranolol for migraine headaches and nadolol for angina pectoris. [Pg.214]

Divalproex sodium is comprised of sodium valproate and valproic acid. The delayed-release and extended-release formulations are converted in the small intestine into valproic add, which is the systemically absorbed form. It was developed as an antiepileptic drug, but also has efficacy for mood stabilization and migraine headaches. It is FDA-approved for the treatment of the manic phase of bipolar disorder. It is generally equal in efficacy to lithium and some other drugs for bipolar mania. It has particular utility in bipolar disorder patients with rapid cycling, mixed mood features, and substance abuse comorbidity. Although not FDA-approved for relapse prevention, studies support this use, and it is widely prescribed for maintenance therapy. Divalproex can be used as monotherapy or in combination with lithium or an antipsychotic drug.31... [Pg.597]

Acute Treatment of Migraine Subcutaneous Placebos Are Better Than Oral Placebos , Journal of Neurology 247 (2000) 183-88 Delgado, Pedro L., Depression The Case for a Monoamine Deficiency , Journal of Clinical Psychiatry 61 (2000) 7-11 Depression Drugs Don t Work, Says New Study , The Times, 26 February 2008... [Pg.199]

FIGURE 53-2. Treatment algorithm for prophylactic management of migraine headaches. (NSAID, nonsteroidal antiinflammatory drug.)... [Pg.622]


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See also in sourсe #XX -- [ Pg.277 ]




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