Microsomes factors which influence

Specifically, we may ask the following questions First, what constitutes amino acid incorporation into protein or protein-like material Second, is all incorporation of amino acids into protein-like material due to a de novo formation of peptide bonds Third, what are the factors which influence the apparent rate of incorporation, both in vivo and in vitro systems Fourth, what is the relationship between incorporation of amino acids into total protein-like material and the synthesis of a specific and independent protein molecule and, finally,- what is the nature of the amino acid incorporation in vitro, particularly in the microsomal system, and its relationship to amino acid incorporation in the intact cell ... 

There are many factors in the environment, which may influence drug disposition, metabolism, and toxicity to a greater or lesser extent. However, as the influence of certain foreign compounds, both drugs and those in the environment, on microsomal enzymes has been well studied, this will constitute a separate section "Enzyme induction and Inhibition". 

Continued reduction or cessation in the formation of oxygen radicals (especially in the area of the mitochondria, nuclear membranes or microsomes) is eventually fatal to the cell. An uncontrolled increase in the cellular formation of superoxide dismutase (as is found in mental disease, trisomy 21, etc.) may also entail dangerous disturbances in the cellular oxygen balance. Moreover, a change in the physicochemical properties of superoxide dismutase under pathological conditions, which may lead to reduced enzyme activity and altered cell compartments, is being discussed as a further influencing factor. 

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