Microfluidic technology sample preparation

In recent years, first prototypes of SPR biosensor systems integrating these elements have been reported and their application for detection of biological analytes in the field have been demonstrated. Undoubtedly, advances in the development of the key elements - sample preparation technology, microfluidics, biomolecular recognition elements, SPR optical platform - will further stimulate this effort and eventually lead to in-field SPR sensor systems becoming a commercial reality. 

The devices based on microfluidic chip-capillary electrophoresis (microchip-CE) make use of the microfluidic chip technology for sample preparation and pretreatment prior to highly efficient separation by capillary electrophoresis using commercially available instrumentation. A list of the research and development work performed using the hyphenated microfluidic chip-CE technique is given in Table 2, showing three major areas of application. 

Both flow-based and array-based chemiluminescence detection systems have been incorporated into micro total analysis systems (pTAS) and other microfluidic devices in conjunction with the myriad recent advances and innovations in microfluidics technology such as device fabrication, sample and reagent preparation and handling, and analyte selectivity, as described throughout this Encyclopedia. 

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