Microfluidic Systems Sensitivity, High Speed

4 CPC Spin Column Eluates Analyzed by ESI/lon Mobility/Mass Spectrometry 

5 CPC Spin Columns with Matrixless MALDI-MS and Gyros CPC Microfluidic ESI/MALDI-MS System 

The author greatly appreciates the technical comments and suggestions of Paul Schnier, Boris Cheskis, Anthony Amin and Scott Mayer and acknowledges his colleagues Ellen Baum, Robert Powers and Franklin Moy for inspiring and encouraging this work. 

Loo Electrospray ionization mass spectrometry a technology For studying noncovalent macromolecular complexes, Int. J. Mass Spectrom. 

Thanabal, H.-Y. Mei Studying noncovalent small molecule interactions with protein and RNA targets by mass spectrometry. Mass Spectrom. Biol. Med. 2000, 2000, 

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Similar to capillaries, the most common detection method for high-speed separations on microdevices is fluorescence, yet few methods have matched the limits of detection found in sheath-flow formats routinely used in capillary systems. This is due in part to the microfluidic substrate being in a planar format and therefore difficult to reproduce the three-dimensional Taylor cone found in sheath-flow capillary systems. The most simple and common method for high-sensitivity detection in microdevices is the use of a confocal detection scheme. ... 

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