Microflow high-pressure processing

The application of high pressure in liquid-phase reactions is less common in microflow when compared to high-temperature processing. However, also pressure can have a pronounced effect on the reaction outcome [23], Reactions that are accompanied by a decrease in volume (activation volume) are typically accelerated by pressure. In addition, equilibrium reactions can be shifted toward the side that has a decrease in volume. As such, the use of pressure can lead to an improvement in chemo-, regio-, and stereoselectivity. Such equipment and procedures are far from the common laboratory setups and practices since these require strict safety precautions. However, miniaturization of the reactor setup allows to alleviate many risks associated with high-pressure chemistry [24]. 

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