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Microfilarial effects, ivermectin

Unfortunately, protozoan flagellates like trypanosomes are unaffected by ivermectin (21) but, at least, the animals that take up the ivermectin (with coccidiostat) will be rid of most gastrointestinal nematodes and ectoparasites. Gxtraintestinal filariasis can also be treated for example, microfilarial dermatitis in horses (22) and even onchocerciasis in humans (23). which is transmitted by the bite of infected black flies (Slmulium spp.). However, the doses required (30 - 50 pg/kg) in the latter case were not without short term side effects. [Pg.420]

For mass treatmerU programs, the introduction of diethylcarbamazine into table salt (0.2-0.4% by weight of the base) has markedly reduced the prevalence, severity, and transmission of lymphatic filariasis in many endemic areas. Diethylcarbamazine given annually as a single oral dose of 6 mg/kg is most effective in reducing microfilaremia when coadministered with either albendazole (400 mg) or ivermectin (0.2-0.4 mg/kg). Adverse reactions to microfilarial destruction usually are well tolerated. However, mass chemotherapy with diethylcarbamazine should not be used in regions where onchocerciasis or loiasis coexist because it may induce severe reactions related to parasite burden in these infections. [Pg.701]

Toxicity, Side Effects, and Precautions Ivermectin generally is well tolerated. In infected humans, ivermectin toxicity nearly always results from reactions to dying microfilariae the intensity and nature of these reactions relate to the microfilarial burden and the duration and type of filarial infection. [Pg.703]

Comparative studies Filariasis Annual mass treatment with albendazole and ivermectin is the mainstay of current strategies to interrupt transmission of Wuchereria bancrofti in Africa. More effective micro-filarial suppression could potentially reduce the time necessary to interrupt transmission, easing the economic burden of mass treatment programs in countries with limited resources. To determine the effects of increased dose and frequency of albendazole 4-ivermectin treatment on microfilarial clearance, 51 W. bancrofti microfilaremic residents of an area of W. bancrofti endemicity in Mali were randomized to receive two doses of annual, standard-dose albendazole -I- ivermectin... [Pg.488]


See other pages where Microfilarial effects, ivermectin is mentioned: [Pg.1150]    [Pg.1227]    [Pg.1263]    [Pg.49]    [Pg.1116]    [Pg.1948]    [Pg.109]    [Pg.110]    [Pg.111]    [Pg.111]    [Pg.406]    [Pg.488]   
See also in sourсe #XX -- [ Pg.406 , Pg.415 ]




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