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Microencapsulation drug stability

Torres Al, Boisdron-Celle M, Benoit JP. Formulation of BCNU-loaded microspheres influence of drug stability and solubility on the design of the microencapsulation procedure. J Microencapsul 1996 13 41-51. [Pg.368]

Heiati, H., Tawashi, R. and Phillips, N.C. (1998) Drug retention and stability of solid lipid nanoparticles containing azidothymidine palmitate after autoclaving, storage and lyophilization. J. Microencapsulation 15, 173-184. [Pg.21]

FIGURE 22.23 Typical stability map of the EHDA, 1% paracetamol in isopropyl alcohol. (Reprinted from Int. J. Pharmaceut., 324, Ciach, T., Microencapsulation of drugs by electro-hydro-dynamic atomization, 51-55, Copyright 2006, with permission from Elsevier.)... [Pg.429]

The drugs, which are sensitive to oxygen, moisture, or light, can be stabilized by microencapsulation. [Pg.1070]

This method was adopted to prepare polyanhydride copolymer of poly(bis(p-carboxy phenoxy) propane anhydride) with sebacic acid. In this method, the polymer is first melted and then mixed with solid particles of the drug. The mixture is suspended in a nomniscible solvent (e.g., silicone oil), continuously stirred, and heated to 5°C above the melting point of the polymer. Once the emnision is stabilized, it is cooled until the polymer particles solidify. The resniting microspheres are washed by decantation with petroleum ether. The primary objective for developing this method is to develop a microencapsulation process suitable for the water-labile polymers, for example, polyanhydrides. Microsphere with diameter of 1-1000 pm can be obtained, and the size distribution can be easily controlled by altering the stirring rate. [Pg.1374]


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See also in sourсe #XX -- [ Pg.2320 , Pg.2321 ]




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