Microemulsion electrokinetic development

Different types of EKC have been developed. Cy-clodextrins (CDEKC) have been used to form inclusion complexes with solutes to effect their separation. Other examples of EKC include microemulsion electrokinetic chromatography (MEEKC). The MEKC technique (for a detailed treatise, the reader is referred to Ref. 4) utilizes the presence of micelles in the electrolyte buffer solution to influence the migration time of solutes. In this case, the separation carrier is the micelle [5]. 

To date, the use of chemometrics for method development and robustness testing has been published for all areas of CE, including capillary zone electrophoresis (CZE), capillary electrokinetic chromatography (EKC) using chiral selectors for enantioseparations, micellar electrokinetic chromatography (MEKC), and microemulsion electrokinetic chromatography (MEEKC). A comprehensive description can be found in Chapters 5 and 13 as well as in recent reviews (6-11). Several monographs on chemometrics in analytical chemistry have been published such as References 12-14. This chapter will... 

McEvoy E., Marsh A., Altria K.D., Donegan S., Power J., Recent advances in the development and apphcations of microemulsion electrokinetic chromatography. Electrophoresis, 28, 193-207 (2007). 

Furlanetto, S., Orlandini, S., Marras, A. M., Mura, P., and Pinzauti, S. (2006). Mixture design in the optimization of a microemulsion system for the electrokinetic chromatographic determination of ketorolac and its impurities method development and validation. Electrophoresis 27, 805-818. 

Several modes of CE have been described in the literature over past decade [6, 7], The most common are open tubular or capillary zone electrophoresis (CZE), micellar electrokinetic chromatography (MEKC), microemulsion elec-trokinetic chromatography (MEEKC), capillary electrochromatograpy (CEC), capillary gel electrophoresis, capillary isoelectric focusing and capillary iso-tachophoresis. Three recent reviews by Watzig [113], Tagliaro etal. [114] and Riekkola etal. [115] summarise the current method development options available to manipulate selectivity. In pharmaceutical analysis, CZE, MEKC, MEEKC and CEC are commonly used. 

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