Microdialysis studies dermal

Many studies demonstrate a modest enhancement in penetration through damaged skin, while several demonstrate an equal and even decreased penetration through damaged skin versus controls. Dermal microdialysis studies, as an exception, show significant enhancanent through perturbed... 

Dermal microdialysis studies were reviewed separately from other studies because penetrant measurement in receiving chambers does not account for flux, nor does it justify metabolism. Moreover, dermal microdialysis may itself alter the barrier function of the skin, and there are unresolved issues relating to mass balance detection. 

Mierodialysis has also been used for topical bioavailability/bioequivalence studies. A correlation has been demonstrated between dermal AUC/C j of topically applied tranilast in six different vehicles assessed with mierodialysis and AUC/C, from plasma concentration-time curves (Murakami, Yoshioka,Yumoto, et al., 1998). However, in another study, no correlation was found between dermal AUC/C j and plasma AUC/Cjjjj, of salicylic acid applied in five different vehicles (Murakami, Yoshioka, Okamoto et al., 1998). These findings emphasize that plasma drug levels do not always correlate with dermal levels assessed by techniques such as microdialysis. The correlation or lack thereof is compound dependent secondary to their... 

Advances of in vivo methods for dermal absorption studies have shown promising results. Microdialysis has bear ranployed successfully for measuring dermal penetration of a wide variety of compounds. This technique has been used extensively in topieal bioavaUabUity and bioequivalenee studies. The noninvasive techniques for percutaneous absorption studies such as tape-stripping, ATR-FTIR, and skin surface biopsies arc also becoming popular because these can be used safely in humans. Regulatory bodies rely on mass balance approaches because all of the topically... 

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