Microchannels micromachined reaction

A ceramic microreaction device with a microchannel (width 400 pm x depth 400 pm X length 40 cm) was fabricated by micromachining. From two separate inlets, the solutions of active ester in DMF and amino acid with triethylamine (added for deprotonation of amino group of amino acid) in water were loaded separately by syringe pumping (Fig. 6). The resulting solution was collected and directly analyzed by HPLC to estimate the conversion rate. Each peak obtained by HPLC was confirmed by ESI-TOFMS. In the case of reaction between... 

Highly resistant materials are required to fabricate microchannel structures that are stable under reaction conditions and to reduce costs. Substitution of stainless steel for silicon is one step toward cost reduction, but this is currently offset by the cost of micromachining and fabrication. Ceramics such as cordierite, mullite (3 Al203-2Si02), alumina (AI2O3), and so on are ideal to reduce heat losses due to... 

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