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Microbubbles destruction

The progression of microbubble destruction in the ultrasound field strongly depends on the intensity and frequency of the ultrasound field. Generally, at low intensity (e.g., MI 0.1, especially when imaging is performed in the intermit-... [Pg.95]

Price RJ, Skyba DM, Kaul S, et al. Delivery of colloidal particles and red blood cells to tissue through microvessel raptures created by targeted microbubble destruction with ultrasound. Circulation 1998 98 1264-1267. [Pg.391]

S. Chen, J. Ding and R. Bekeredjian, et ai, Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology, PNAS, 103(22), 8469-8474 (2006). [Pg.786]

Ultrasound-Targeted Microbubble Destruction (UTMD) for Cardiovascular Gene Therapy... [Pg.360]

Fig. 12.6 Action of ultrasound targeted microbubble destruction. Microbubbles are attached with drugs or genes... Fig. 12.6 Action of ultrasound targeted microbubble destruction. Microbubbles are attached with drugs or genes...
By using microbubble destructive techniques, such as stimulated acoustic emission (SAE), or agent detection imaging (ADI), it is possible to exploit the liver specific phase of some agents, which is probably mediated by Kupffer cell uptake. Interaction with... [Pg.123]

Yasui K, Lee J, Tuziuti T, Towata A, Kozuka T, Iida Y (2009) Influence of the bubble-bubble interaction on destruction of encapsulated microbubbles under ultrasound. J Acoust Soc Am 126 973-982... [Pg.28]

Interestingly, we have found that microbubble deflation in the ultrasound field is unusually slow for the microbubbles that contain perfluorocarbon gas when the surrounding medium is depleted of air and saturated with the same fluorocarbon gas [57]. So, perhaps in an air-saturated environment the ultra-sound-mediated destruction of microbubbles may depend on the influx of air into the bubbles, not just on the perfluorocarbon loss. [Pg.90]

Another example of a delivery system based on microbubbles and ultrasound is the delivery of circulating microparticles (polymer latex beads) or fluorescent red blood cells outside of the capillaries into the surrounding tissues by the action of ultrasound on the co-injected Optison microbubbles [79]. Interestingly, polymer beads and red blood cells could be detected tens of micrometers away from the capillaries where the bubble destruction took place. This may imply that during rapid destruction of a microbubble in a very strong ultrasound field, adjacent microsphere beads in the bloodstream can be propelled deep into the surrounding tissues. [Pg.97]

Shohet RV, Chen S, Zhou YT, Wang Z, Meidell RS, Unger RH, Grayburn PA (2000) Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium. Circulation 101 2554-2556... [Pg.485]

D.M. Skyba, et al.. Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue, Circulation 98 (4) (1998) 290-293. [Pg.386]

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See also in sourсe #XX -- [ Pg.83 , Pg.88 , Pg.89 , Pg.90 , Pg.94 , Pg.95 , Pg.96 , Pg.97 ]



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