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Microbial cultures, antifungal activities

Bisabosqual A (40) was isolated from the culture broth of Stachybotrys sp. RF-7260. Its structurally related compounds, bisabosquals B (41), C (42) and D (43) were also isolated from Stachybotrys ruwenzoriensis RF-6853. All the bisabosqual compounds inhibited squalene synthases of microbial and mammalian origins. Bisabosqual A showed significant inhibitory activity against the microsomal squalene synthases from HepG2 cells and rat liver. Its IC50 values were 0.95 and 2.5 p g/mL, respectively. Bisabosqual A also showed broad-spectrum antifungal activity in vitro. Bisabosqual C exhibited inhibitory activities similar to those of bisabosqual A [67, 68]. [Pg.772]

See other pages where Microbial cultures, antifungal activities is mentioned: [Pg.11]    [Pg.2]    [Pg.161]    [Pg.409]    [Pg.282]    [Pg.285]    [Pg.748]    [Pg.28]    [Pg.3575]   
See also in sourсe #XX -- [ Pg.409 ]



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