Micro mass spectrometer

Mass spectrometers must be regularly tuned or calibrated against a known standard, e.g. perfluorotributy-lamine (PFTBA). The trend is towards miniaturisation (10 x 24 x 14 in.). A concept for a micro mass spectrometer, with potential applications in process monitoring, has been presented [167]. Mass-spectrometry instrumentation (1997) has been reviewed [166]. 

The intention of this contribution is to demonstrate that such a micro-mass spectrometer can be realized with features which in part resemble that of state-of-the-art spectrometers for standard applications closely and that the state of the art of this system is at the verge to make it a commercial, easily to handle analytical system. 

Such an approach is evidently inherently rather challenging, since mostly due to the restriction to a 2V2-D geometry in a single material at least part of the subsystems will need a complete redesign as compared to established mass spectrometer geometries or even the introduction of alternative physical principles with completely new structures. Furthermore, all subsystems must be compatible with respect to fabrication, size, function, and pressure regime as well as electrical interfaces. Finally such a micro-mass spectrometer will need a modified and adapted hardware and software of the electronics—which actually means a completely new one. 

Wapelhorst E, Hauschild J-P, Muller J (2007) Complex MEMS a fully integrated TOF micro mass spectrometer. Sensors and Actuators A 138 22-27... 

Ramirez Wong RM, Hauschild J-P, Wapelhorst E, Muller J (2009) Optimization of Microplasma for the Application in a Micro Mass Spectrometer. VDE, Berlin... 

Reinhardt M, Quiring G, Ramirez Wong RM, Wehrs H, Muller J (2010) Helium detection using a planar integrated micro-mass spectrometer. International Journal of Mass Spectrometry 295 145-148... 

The planar integrated micro mass spectrometer—one of the new mass spectrometers under development—is also introduced here. Such a portable handheld micro mass spectrometer would be very useful for bedside therapeutic drug monitoring. 

LC-MS/MS System Used and Analytical Conditions LC-10 Advp and controller SCL-10 Avp (Shimadzu Scientific Instruments, USA) connected to a Micromass Quattro Micro mass spectrometer (Micromass, UK). The mass spectrometer was equipped with an Electrospray ionization source. 

Nordstrom et al. [121] also compared the differences between UPLC and HPLC for metabolomic profiling. This time a Waters Acquity system was coupled to Micromass Q-Tof-Micro mass spectrometer and data were acquired in the m/z 100-1000 range with an acquisition of 2 spectra per second. About 20% more components were detected using UPLC versus HPLC and the length of the chromatographic separation was one of the most crucial parameters affecting the number of detected features. These examples demonstrate the importance of appropriate mass analyzers when utilizing UPLC. For more on UPLC see Chapter 8. 

Figure 3.10 Gradient separation of ibuprofen metabolites from a human urine sample on a 2.1 by 100mm reversed-phase C18 column using a TriVersa Nano-Mate coupled with a Waters Q-TOF micro mass spectrometer. (A) Extracted ion chromatogram for carboxy-ibuprofen-diglucuronide with MH+ at m/z 589.3 and (B) base peak intensity chromatogram. LC fractions were collected simultaneously every 15 s into a 384-well plate.

Micro-mass spectrometer for containment gas monitoring Neuron Chip... 

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